Tuberculin Purified Protein Derivative (Mantoux) Tubersol Diagnostic Antigen DESCRIPTION Tuberculin Purified Protein Derivative (Mantoux) - TUBERSOL for intradermal (Mantoux) tuberculin testing is available in a stabilized solution
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DESCRIPTION Tuberculin Purified Protein Derivative (Mantoux) TUBERSOL for intradermal (Mantoux) tuberculin testing is available in a stabilized solution bio-equivalent to 5 U.S. units (TU) PPD-S per test dose (0.1 mL). TUBERSOL is prepared by Aventis Pasteur Limited from a large Master Batch, Connaught Tuberculin (CT68) and is a cell-free purified protein fraction obtained from a human strain of Mycobacterium tuberculosis grown on a protein-free synthetic medium, and inactivated. TUBERSOL is a sterile isotonic solution of Tuberculin in phosphate buffered saline containing Tween 80 (0.0005%) as a stabilizer. Phenol 0.28% is added as a preservative. Prior to release, each successive lot is tested for potency in sensitized guinea pigs in comparison with the U.S. Standard Tuberculin PPD-S.
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Lymphangitis after tuberculin test.
After Mantoux testing with purified protein derivative (PPD) equivalent to 5 tuberculin units (TU), a 28 yr old man developed extensive erythema, induration and proximal lymphangitis. This is the only such case observed after Mantoux testing in approximately 500,000 subjects during 10 yrs in the Greek Army.
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Tuberculosis is a common disease in India. Mantoux test is used in children for diagnosis of tuberculosis. Seibert first prepared the purified protein derivative (PPD) from heat-concentrated old tuberculin by precipitating protein initially with trichloroacetic acid(l). PPD when diluted is adsorbed by glass and plastic surfaces. To minimize this a small amount of detergent. Tween-80, is added t...
متن کاملExtent and Effects of Recurrent Shortages of Purified-Protein Derivative Tuberculin Skin Test Antigen Solutions — United States, 2013
Two purified-protein derivative (PPD) tuberculin skin test (TST) antigen solutions are approved by the U.S. Food and Drug Administration (FDA): Tubersol (Sanofi Pasteur Limited) and Aplisol (JHP Pharmaceuticals, LLC). Tubersol was out of production in late 2012 through April 2013. Shortages of Aplisol have resulted from increased demand as practitioners have sought a substitute for Tubersol. Tu...
متن کاملComparable specificity of 2 commercial tuberculin reagents in persons at low risk for tuberculous infection.
CONTEXT One or both commercial tuberculin skin test reagents (Aplisol and Tubersol) may have a high rate of false-positive reactions. OBJECTIVE To compare the reaction size and specificity of skin testing with Aplisol, Tubersol, and the standard purified protein derivative (PPD-S1). DESIGN Double-blind trial, conducted between May 14, 1997, and October28, 1997, in which each individual rece...
متن کاملDifferences in tuberculin reactivity as determined in a veterans administration employee health screening program.
In response to a difference in pricing, the San Diego Veterans Administration Medical Center changed its tuberculin preparation from Tubersol to Aplisol in the fall of 2006. Following the change, an increased number of employee skin test conversions was noted. Employee tuberculin skin test converters from 2006 were screened with the QuantiFERON Gold (QFT-G) gamma interferon release assay. Those...
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